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Overall structure of MTHFD2/15/21 (PDB 7EHM). Monomer A is depicted in teal and monomer B in pink. Helices B, D, D1, D2, D2′, and E and the β-sheets e and f are marked. 15 (xanthine derivative) and 21 (folate analogue) are shown in yellow and gray, respectively. The βe-αE loop, αD2′-αD3′ loop, and αE′-βf′ loop are also highlighted in magenta.
