Table 2. IC50 Values Obtained with the MTT Assay following 72 h Treatment with Ciprofloxacin (Cip), Norfloxacin (Nor), and Their Derivatives.
| IC50 (μM) ± ESa |
IC50 (μM) ± ESa |
||||
|---|---|---|---|---|---|
| Compd | WH1 | HBL100 | Compd | WH1 | HBL100 |
| 1a | 9.17 ± 0.60 | 7.79 ± 0.66 | 1b | 5.35 ± 1.14b | 9.26 ± 1.79 |
| 3a | 8.38 ± 1.20 | 10.57 ± 2.40 | 3b | 9.00 ± 1.91 | 11.95 ± 1.70 |
| 6a | 10.5 ± 2.50 | 9.76 ± 0.90 | 6c | 10.63 ± 1.90 | 10.85 ± 0.60 |
| 6b | 13.2 ± 3.40 | 12.21 ± 2.00 | 6d | 9.67 ± 1.65 | 3.68 ± 0.20b |
| 7a | 5.70 ± 0.92 | 9.14 ± 0.44 | 7c | 3.51 ± 0.40b | 11.09 ± 0.20 |
| 7b | 7.05 ± 1.20 | 9.19 ± 0.66 | 7d | 8.94 ± 0.91 | 10.40 ± 0.90 |
| Cip | 14.2 ± 2.10 | 10.28 ± 1.00 | Nor | 14.07 ± 2.10 | 12.43 ± 0.80 |
a
Mean ± ES 4/5 independent experiments.
b
p < 0.05 vs Nor.