. 2021 Jul 16;125(29):8048–8059. doi: 10.1021/acs.jpcb.1c04547

Table 5. Effect of Cholesterol on the Binding Mode Characteristics.

	POPE		POPE + cholesterol
binding mode	P_b (%)	residence time (ns)	P_b (%)	residence time (ns)
phosphate group (direct)	1.2	250	2.4	250
ethanolamine group	18.2	8.1	21.4	10.1
phosphate group (water-mediated)	21.0	6.0	18.7	5.5

	DMPC		DMPC + cholesterol
binding mode	P_b (%)	residence time (ns)	P_b (%)	residence time (ns)
glycerol moiety	1.2	500	1.2	500
phosphate group (water-mediated)	13.4	5.8	10.7	3.9
choline group (water-mediated)	7.9	1.3	9.3	1.3