Table 1. Antimicrobial Activity of the Designed Cyclic 9-Derived Peptides^b.

^aLowercase letters in italic indicate amino acids in d-configuration. Pra = propargylalanine; Az = azidolysine; S₅ = (S)-2-(4-pentenyl)alanine.

^bAliquots (50 μL) of bacteria in mid-log phase (final concentration of 1 × 10⁶ colony-forming units (CFU)/mL) in the Mueller–Hinton broth (MH) were added to 50 μL of MH broth containing the peptide in serial twofold dilutions. The minimal inhibitory concentration (MIC) was defined as the concentration (μM) of peptide at which 100% inhibition of microbial growth was observed, after an incubation of 16–18 h at 37 °C.