Table 1.

Sensitivity analysis of cutoff point of NLR.

Sensitivity analysis cutoff point in our exploratory study
	Method	Cutoff	C-index	Sensitivity	Specificity	Low NLR, no. of dead (%)	High NLR, no. of dead (%)	HR; 95%CI, P value
Our study	Continuous	–	0.535	–	–	–	–	1.07; 1.01 to 1.13, .019
	Median	2.6	0.539	54.0%	53.6%	97/232 (42%)	114/231 (49%)	1.31; 1.00 to 1.72, .048
	Maximum C-index∗	3.0	0.548	41.7%	67.9%	123/294 (42%)	88/169 (52%)	1.43; 1.09 to 1.89, .010
	Mean	3.2	0.539	35.6%	73.0%	136/320 (43%)	75/143 (52%)	1.39; 1.05 to 1.84, .023
	High sensitivity	1.6	0.510	80%	16.7%	40/80 (50%)	171/383 (45%)	0.89; 0.63 to 1.26, .519
	High specificity	3.8	0.529	27%	80%	154/357 (43%)	57/106 (53%)	1.38; 1.02 to 1.87, .037
Sensitivity analysis of cutoff point from previous report
Lin et al[11]	AuROC	2.2	0.510	63.5%	37.3%	77/171 (45%)	134/292 (46%)	1.10; 0.83 to 1.45, .523
Lu et al[12]	AuROC	2.3	0.517	61.1%	41.67%	82/187 (44%)	129/276 (47%)	1.15; 0.87 to 1.52, .325
Li et al[8]	AuROC	2.5	0.532	55.5%	50.4%	94/221 (43%)	117/242 (48%)	1.26; 0.96 to 1.65, .094
Sun et al[6]	AuROC	2.6	0.539	54.0%	53.6%	97/232 (42%)	114/231 (49%)	1.31; 1.00 to 1.72, .048
Jiang et al[4]	AuROC	2.7	0.536	49.8%	57.9%	106/252 (42%)	105/211 (50%)	1.32; 1.01 to 1.73, .046
Liao et al[10]	Mean	3.6	0.530	29.9%	77.8%	148/344 (43%)	63/119 (53%)	1.34; 1.00 to 1.80, .050
An et al[7]	AuROC	3.7	0.528	28.4%	56.2%	152/352 (43%)	590111 (53%)	1.35; 1.00 to 1.83, .049
Chua et al[15]	Median	3.0	0.548	41.7%	67.9%	123/294 (42%)	88/169 (52%)	1.43; 1.09 to 1.89, .010
	P80th	4.2	0.537	23.7%	84.9%	161/375 (43%)	50/88 (57%)	1.57; 1.14 to 2.15, .006

CI = confidence interval, C-index = concordance index, HR = hazard ratio, NLR = neutrophil-to-lymphocyte ratio, AuROC = area under the receiver operating characteristic curve.