Table 3.

Overall survival of neutrophil-lymphocyte ratio (NLR) with cutoff value 3.0 in models 1 to 3 and internal validation with bootstrapping technique.

	Model 1∗		Model 2†		Model 3‡
	HR; 95% CI, P value	C-index (95% CI)	HR; 95% CI, P value	C-index (95% CI)	HR; 95% CI, P value	C-index (95% CI)
NLR	1.43; 1.09 to 1.89, .010	0.548 (0.512–0.583)	1.34; 1.01 to 1.79, .040	0.674 (0.646–0.717)	1.34; 1.01 to 1.76, .040	0.645 (0.608–0.679)
AJCC stage
Stage II			1.73; 0.23 to 12.87, .590		2.20; 0.30 to 16.29, .439
Stage III			2.25; 0.31 to 16.38, .422		2.75; 0.38 to 19.94, .316
Stage IVa			5.16; 0.72 to 37.20, .103		6.21; 0.87 to 44.44, .069
Age			1.03; 1.02 to 1.04, .001
Gender			1.31; 0.96 to 1.80, .091
BMI			0.99; 0.96 to 1.03, .740
Histology
NK, diff			0.66; 0.21 to 2.09, .479
NK, undiff			0.49; 0.16 to 1.56, .228
Internal validation§		0.547 (0.531–0.566)		0.663 (0.651–0.686)		0.642 (0.627–0.661)

^∗Model 1 included NLR by cutoff value 3.0.

^†Model 2 included NLR by cutoff value 3.0, AJCC stage, age, gender, body mass index (BMI), and histology.

^‡Model 3 included NLR by cutoff value 3.0, and AJCC stage.

^§After adjusted slope to coefficient.

CI = confidence interval, C-index = concordance index, HR = hazard ratio.