Table 4.
Results of univariate and multivariable analysis for disease severity
|
Univariate analysis |
Multivariable analysis |
||||
|---|---|---|---|---|---|
| p value | Odds ratio (95% CI) | p value | Odds ratio (95% CI) | ||
| Income group | <0·0001 | .. | <0·0001 | .. | |
| Low-income or lower-middle-income country | .. | 3·5 (2·5–4·9) | <0·0001 | 5·8 (3·8–8·8) | |
| Upper-middle-income country | .. | 1·6 (1·3–2·1) | 0·0024 | 1·6 (1·2–2·2) | |
| High-income country | .. | 1 (ref) | .. | 1 (ref) | |
| Cancer type | <0·0001 | .. | 0·14 | .. | |
| Acute lymphoblastic leukaemia or acute lymphoblastic lymphoma | .. | 2·0 (1·6–2·6) | 0·086 | 1·4 (1·0–2·0) | |
| Other haematological malignancies | .. | 2·3 (1·6–3·1) | 0·55 | 1·2 (0·8–1·9) | |
| Solid tumours | .. | 1 (ref) | .. | 1 (ref) | |
| CNS tumours | .. | 0·7 (0·5–1·0) | 0·53 | 0·9 (0·5–1·5) | |
| Age, years | 0·0015 | .. | 0·046 | .. | |
| <1 | .. | 0·7 (0·4–1·4) | 0·99 | 1·0 (0·5–2·4) | |
| 1–9 | .. | 1 (ref) | .. | 1 (ref) | |
| 10–14 | .. | 1·1 (0·8–1·4) | 0·53 | 0·9 (0·7–1·3) | |
| 15–18 | .. | 1·7 (1·3–2·3) | 0·013 | 1·6 (1·1–2·2) | |
| Sex | 0·14 | .. | .. | .. | |
| Male | .. | 1 (ref) | .. | .. | |
| Female | .. | 1·2 (1·0–1·4) | .. | .. | |
| Absolute lymphocyte count, cells per mm3 | <0·0001 | .. | <0·0001 | .. | |
| ≤300 | .. | 3·6 (2·7–4·8) | <0·0001 | 2·5 (1·8–3·4) | |
| >300 | .. | 1 (ref) | .. | 1 (ref) | |
| Absolute neutrophil count, cells per mm3 | <0·0001 | .. | 0·0001 | .. | |
| ≤500 | .. | 3·2 (2·5–4·2) | 0·0001 | 1·8 (1·3–2·4) | |
| >500 | .. | 1 (ref) | .. | 1 (ref) | |
| Comorbidities | 0·0001 | .. | 0·074 | .. | |
| Yes (one or more) | .. | 1·7 (1·3–2·2) | 0·074 | 1·4 (1·0–1·9) | |
| None | .. | 1 (ref) | .. | 1 (ref) | |
| Intensive treatment | <0·0001 | .. | 0·0005 | .. | |
| Yes | .. | 2·3 (1·9–2·9) | 0·0005 | 1·8 (1·3–2·3) | |
| No | .. | 1 (ref) | .. | 1 (ref) | |
Data shown for 1301 participants.