Table 1.
Overview of baseline characteristics, standard CSF parameters and phenotyping results
| Total N = 57 | ME n = 29 | NIMM n = 22 | NIND n = 6 | p1 Global Test | p2 ME vs. NIMM | |
|---|---|---|---|---|---|---|
| Age median (range) | 52 (20;88) | 59 (20;88) | 47 (21;75) | 49 (32;78) | 0.70a | – |
| Female n (%) | 26 (45.6) | 12 (41.4) | 12 (54.5) | 2 (33.3) | 0.53b | – |
| Routine CSF Parameters: | ||||||
| Cells/µl mean (SD) | 83.8 (190.0) | 137.1 (246.0) | 35.8 (85.2) | 1.83 (0.75) | < 0.0001c | < 0.0001c |
| QAlb mean (SD) | 16.8 (21.7) | 23.0 (26.5) | 11.5 (14.4) | 6.15 (1.65) | < 0.001c | 0.005c |
| Intrathecal IgG synthesis (P/N) | 17/40 | 6/23 | 11/11 | 0/6 | 0.020b | 0.63b |
| →% IgG mean (SD) | 7.30 (15.5) | 4.93 (15.0) | 12.4 (17.2) | 0.00 (0.00) | 0.009c | 0.14c |
| CXCL13 pg/ml mean (SD) | 281.7 (425.4) | 423.8 (492.2) | 170.3 (310.8) | 3.25 (4.08) | < 0.0001c | 0.002c |
| Immune cell phenotyping | % | % | % | % | p1 | p2 |
|---|---|---|---|---|---|---|
| CD19 + mean (SD) | 4.68 (5.96) | 5.28 (6.63) | 4.25 (4.67) | 3.37 (7.43) | 0.54c | – |
| CD3+CD4 mean (SD) | 61.7 (12.8) | 59.3 (11.3) | 66.6 (11.7) | 55.7 (18.7) | 0.05c | – |
| →CXCR5+CD4 mean (SD) | 20.5 (7.46) | 22.6 (8.22) | 19.3 (6.01) | 14.7 (4.41) | 0.020c | 0.10c |
| CD3 + CD8 mean (SD) | 25.6 (10.8) | 26.0 (10.5) | 22.9 (9.86) | 33.7 (12.6) | 0.08c | 0.25c |
| →CXCR5+CD8 mean (SD) | 12.7 (9.27) | 14.9 (9.96) | 10.9 (7.20) | 8.90 (11.4) | 0.13c | – |
| Cells/µl | Cells/µl | Cells/µl | Cells/µl | p1 | p2 | |
|---|---|---|---|---|---|---|
| CD19+ mean (SD) | 2.25 (4.05) | 3.61 (5.11) | 1.06 (1.84) | 0.05 (0.12) | < 0.0001c | < 0.001c |
| CD3 + CD4 mean (SD) | 31.8 (56.1) | 46.5 (58.9) | 20.9 (55.4) | 0.64 (0.39) | < 0.0001c | 0.006c |
| →CXCR5+CD4 mean (SD) | 7.88 (16.4) | 12.1 (20.0) | 4.40 (11.3) | 0.09 (0.06) | < 0.0001c | < 0.001c |
| CD3+CD8 mean (SD) | 12.4 (20.7) | 18.5 (22.6) | 7.48 (18.53) | 0.40 (0.28) | < 0.0001c | 0.002c |
| →CXCR5+CD8 mean (SD) | 1.83 (3.10) | 3.00 (3.74) | 0.77 (1.74) | 0.05 (0.08) | < 0.0001c | < 0.0001c |
Bold values represent significant p values
CD19+, B cells; CXCR5+CD4, CXCR5+CD4 T cells; CXCR5+CD8, CXCR5+CD8 T cells; CSF, cerebrospinal fluid; CSF %IgG, intrathecal IgG synthesis in percent; ME, meningoencephalitis; NIMM, neuroimmunological disease; NIND, non-inflammatory neurological disease; P/N, positive/negative; QAlb, CSF/Serum Albumin Quotient
aANOVA
bChi Square
cGeneralized linear model with Tweedie distributions