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. 2021 Aug 27;19:211. doi: 10.1186/s12916-021-02060-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effective reproduction numbers for the nosocomial spread of the SARS-CoV-2 variant for each simulation scenario. Results shown are based on R_S = 1.95 and R_A = 0.8 (reproduction numbers for the SARS-CoV-2 variant with 56% higher transmissibility with respect to the wild-type SARS-CoV-2 variant). Horizontal dashed lines represent a reproduction number of 1. Summary statistics were calculated for 100 simulations. A For each intervention scenario, violin and boxplots of the overall effective reproduction numbers (for pre-/symptomatic and asymptomatic patients and HCWs combined) are shown. B For each intervention scenario, violin and boxplots of the effective reproduction numbers for pre-/symptomatic and asymptomatic individuals are shown. Since HCWs are assumed to immediately self-isolate upon symptom onset, the reproduction number is assigned to the pre-symptomatic state. For screening every 3 days and 7-day contact tracing prior to symptom onset of SARS-CoV-2 infected HCWs, we considered two different test sensitivity scenarios: time-invariant perfect test sensitivity (perfect sens) and time-varying test sensitivity.