Fig. 2.

Cross-sectional analysis of single-cell RNA-seq blood datasets. (A) Uniform manifold approximation and projection (UMAP) of blood cells obtained from control, moderate, severe, and deceased subjects. Cells were clustered based on similar gene expression levels and colored by cell type. (B) Stacked bar chart showing the cell type proportion based on disease severity. Significantly altered cell types (CD4⁺ T cells, CD14⁺ monocytes, CD16⁺ monocytes) are presented in separate graphs along with their respective numbers in the different COVID-19 severities.