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. 2021 Aug 19;2021:6674204. doi: 10.1155/2021/6674204

Figure 5.

Figure 5

Small interfering RNA targeting fatty acid synthase (siFASN) significantly suppressed p-ERK1/2/Bcl-xL pathway activation in anoikis resistant gastric cancer cells. (a) Representative pictures of the protein levels of phosphorylated (p)-ERK1/2, ERK1/2 and Bcl-xL in MNK-45 and AGS cells in the anoikis resistance (AR), AR + small interfering RNA negative control (siNC), AR + siFASN groups during western blot. β-Actin was used as a loading control. (b) Quantitative analysis of p-ERK1/2, ERK1/2 and Bcl-xL expressions normalized to β-actin through western blot. (c) The Relative ratio of p-ERK1/2 to ERK1/2 expression. ^ p <0.05 vs. AR + siNC group; ^^ p < 0.01 vs. AR + siNC group; ^^^ p <0.001 vs. AR + siNC. Data were performed as the means ± standard.