Fig. 6.

Knockdown of VIRMA enhances sensitivity to cisplatin in vivo. A – Histological view of residual tumors after cisplatin treatment in both scramble and VIRMA knockdown conditions. Notice the higher residual cellularity in scramble conditions, with clear atypia, mitotic figures (blue arrows) and irregular nuclear contour (black box inset). Compare with one of the two VIRMA knockdown tumors showing residual viable tumor cells after cisplatin, where only a very small cluster of individual cells remained across the whole sections (red arrows); B and C – Presence of residual viable tumor cells and estimated cellularity (normalized to the size of tumor mass with necrosis) after cisplatin treatment in scramble and VIRMA knockdown conditions. * p < 0.05