Table 1. Genetic candidate regions of Stmm loci and other cancer susceptibility loci in the vicinity.
| Locus name | Chromosome No. | Genetic marker | rs No. | Candidate region# (bp) | Tumor category | Effect of p53 | Other cancer susceptibility QTLs in the visinity | References |
|---|---|---|---|---|---|---|---|---|
| Stmm1a | 7 | D7Mit351–D7Mit149 | – | 96,776,254–99,188,960 | Early papilloma | Independent | - | [57], Okumura et al. (Unpablished data) |
| Stmm1b | 7 | D7Mit53–D7Mit253 | – | 110,583,818–115,356,689 | Early-middle papilloma | Independent | - | [57, 58, 59] |
| Stmm2 | 7 | D7Mit255–D7Mit259 | – | 124,705,587–144,566,894 | Early-middle papilloma | Independent | Skts2 | [25, 26, 57, 58] |
| Stmm3 | 4 | D4Mit26–D4Mit166 | – | 88,535,066–93,366,888 | Late papilloma, SCC | Dependent | Skts7,Skts-fp1 | [22, 25, 57, 60, 61] |
| Stmm4 | 6 | D6SNP511–D6SNP511512 | rs30149679–rs38226370 | 55,547,013–108,360,689 | Middle papilloma | Independent | Skts11 | [25, 57] |
| Stmm5 | 5 | D5SNP12–D5SNP6 | rs13478361–rs3023057 | 83,810,839–126,154,436 | Middle-late papilloma, SCC | Dependent | Hcs5,Thyls2 | [57, 62, 63] |
| Stmm6 | 3 | D3SNP519* | rs46831546 | 45,778,132 ± 10,000,000 | Middle papilloma | Unknown | - | [57] |
| Stmm7 | 3 | D3SNP504* | rs30553837 | 111,903,098 ± 20,000,000 | Middle papilloma | Unknown | Raml2 | [57, 64] |
| Stmm8 | 12 | D12SNP12* | rs3682985 | 70,353,327 ± 20,000,000 | Middle papilloma | Unknown | Par3 | [57, 65] |
| Stmm9 | 13 | D13SNP12* | rs3698421 | 71,839,279 ± 20,000,000 | Middle papilloma | Unknown | Pas10 | [57, 66] |
| Stmm10 | 17 | D17SNP19–D17SNP510 | rs3705342–N.D. | 68,392,183–94,100,159 | Middle papilloma | Unknown | Skts10 | [25, 57] |
| Stmm11 | 11 | D11SNP8* | rs3023316 | 117,028,591 ± 15,000,000 | Middle-late papilloma, SCC | Unknown | Par1 | [57, 67, 68] |
| Stmm12 | 1 | D1SNP11–D1SNP512 | rs3688428–rs38697954 | 4,137,358–32,741,433 | Early papilloma | Unknown | Lscc1 | [57, 69] |
Early papilloma, tumor diameter of <2 mm; middle papilloma, tumor diameter of 2–6 mm; late papilloma, tumor diameter of >6 mm; SCC, squamous cell carcinoma; N.D., not detected. *Linkage peak. #Candidate regions are based on MGI data.