. 2021 Jun 24;3(9):e648–e658. doi: 10.1016/S2665-9913(21)00116-8

Table 4.

Secondary binary clinical outcomes at 2 years

	Symptoms or structure	Patients with available outcome data in total cohort	Patients with positive outcome in available dataset	Patients with positive outcome in total cohort
NHANES frequent knee pain at 2 years	Symptoms	64/150 (43%)	24/64 (38%)	24/150 (16%)
New radiographic TF knee osteoarthritis^*^†	Structure	56/150 (37%)	22/56 (39%)	22/150 (15%)
OARSI-MRI criteria,²⁰ either new TF osteoarthritis or new PF osteoarthritis^‡	Structure	52/150 (35%)	14/52 (27%)	14/150 (9%)
Luyten early knee osteoarthritis criteria²¹	Symptoms and structure	81/150 (54%)	26/81 (32%)	26/150 (17%)
New symptomatic^§, and radiographic^* osteoarthritis	Symptoms and structure	61/150 (41%)	9/61 (15%)	9/150 (6%)

Data are n/N (%) unless otherwise specified. NHANES=National Health and Nutrition Examination Survey. TF=tibiofemoral. OASRI=Osteoarthritis Research Society International. PF=patellofemoral. KLG=Kellgren and Lawrence grade for osteoarthritis.

Baseline KLG is 0 or 1 and KLG at 2 years is 2 or more.

^†

X-ray available at both baseline and 2 years.

^‡

MRI available at both baseline and 2 years.

^§

Defined by NHANES.