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. 2021 May 4;23(10):2141–2154. doi: 10.1007/s12094-021-02621-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Genes from the 42-gene low-response signature have prognostic value in pediatric AML. a, b Two genes encoding respiratory chain complex I subunits, NDUFA3 and NDUFA6, demonstrated significantly worse EFS for patients with expression levels in the highest quartile (Q4), compared to those with lower expression. c Patients with expression of the signaling regulator CAVIN3 in the highest quartile (Q4) had significantly lower EFS than those in quartiles 1–3. d Patients with expression of the HIF1α target ANKRD37 in quartiles 2–4 had significantly inferior outcomes compared to patients with expression in the lowest quartile (Q1). Kaplan–Meier estimates are based on clinically annotated RNA-seq data for 1061 patients in the TpAML dataset. Log-rank p-values are shown