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. 2021 Jul 15;105(14-15):5719–5737. doi: 10.1007/s00253-021-11424-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Summary of cobalamin genetics, biosynthesis, and regulation in Priestia megaterium DSM319. Upper part: cobalt and cobalamin transporters are indicated in yellow, cobalt in pink, and cobalt chaperon in green. Middle part: summary of cobalamin biosynthesis starting from 8 molecules of 5-aminolevulinic acid. The final product here is shown as adenosylcobalamin which can interact with the cobalamin riboswitches. CobI and CobII indicate all enzymes encoded by the cobI and cobII operons shown below. Lower part: all genes are represented as colored arrows. Black arrows upstream of the operons/single genes indicate promoters, black “T”s terminators and black stem-loop structures cobalamin riboswitches. All genes clustered in operons or situated on their own are annotated. Hypothetical genes are annotated as open reading frames (bmd_0000) as shown in www.megabac.tu-bs.de.