Figure 1.

HSPC mobilization induced by filgrastim and plerixafor in patients with Fanconi anemia

(A) Schematic representation of the CD34⁺ cell mobilization protocol based on the subcutaneous injection of filgrastim (twice daily; 12 μg/kg/12 h for up to 8 days) and plerixafor (240 μg/kg body weight/day; up to 4 doses). After each administration of plerixafor, CD34⁺ cell numbers were determined, and aphereses were initiated when numbers were higher than 5 CD34⁺ cells/μL PB. (B–D) kinetics of PB leukocytes, CD34⁺ cells, and CFCs, respectively, at different time points after administration of the mobilizing drugs. (E) increment of CD34⁺ cells and CFCs at the peak of mobilization compared to basal numbers determined at visit 0. Data corresponding to each of the treated patients are represented by a different color according to the ID indicated in the figure.