Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 26;12:5135. doi: 10.1038/s41467-021-25479-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Quantification of serum antibody levels (EC50) that recognize RBD protein corresponding to the wild-type (WA1)(blue circles), B.1.1.7 (orange squares), and B.1.351 (green triangles) variants. n = 50 biologically independent samples. Data are presented as the mean ± SD of log transformed values. b Comparison of neutralization titers between WA1, B.1.1.7, and B.1.351 for convalescent sera. n = 44 biologically independent samples. c Relationship between convalescent antibody levels and neutralization (FRNT50) of the different viral variants. d, e Correlations between convalescent serum neutralization titer of the B.1.1.7 (d) and B.1.351 (e) variants with the WA1 virus. The dotted diagonal lines indicate identical neutralization, and the solid diagonal black lines indicate 10-fold differences in neutralization. f Violin plots indicating FRNT50 values for WA1 (blue), B.1.1.7 (orange), and B.1.351 (green), stratified by the number of days between the date of confirmatory COVID-19 PCR test and the date of serum sample collection. Black bars indicate median FRNT50 for each group. For a, b, f P values are two-sided and include a Šidák multiple comparison correction. All experiments were performed in duplicate.

HHS Vulnerability Disclosure