Table 1.
Altered biological pathways in immortalized erythroid cell lines compared to equivalent primary cells
| Pathway name |
|---|
| Oncogene-Induced Senescence |
| Diseases of Cellular Response to Stress |
| Diseases of Cellular Senescence |
| Cellular Senescence |
| Evasion of Oxidative Stress-Induced Senescence Due to p16INK4A Defects |
| Evasion of Oncogene-Induced Senescence Due to p16INK4A Defects |
| Evasion of Oxidative Stress-Induced Senescence Due to Defective p16INK4A Binding to CDK4 and CDK6 |
| Evasion of Oncogene-Induced Senescence Due to Defective p16INK4A Binding to CDK4 and CDK6 |
| Oxidative Stress-Induced Senescence |
| Cyclin D-Associated Events in G1 |
| G1 Phase |
| Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A Binding to CDK4 |
| Evasion of Oncogene-Induced Senescence Due to Defective p16INK4A Binding to CDK4 |
| Aberrant Regulation of Mitotic G1/S Transition in Cancer Due to RB1 Defects |
| Defective Binding of RB1 Mutants to E2F1,(E2F2, E2F3) |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| Apoptotic Execution Phase |
| Cellular Responses to External Stimuli |
| Mitotic G1 Phase and G1/S Transition |
| Diseases of Mitotic Cell Cycle |
Pathways generated by input of proteins where abundance differed by ≥2-fold in all of the BEL-C, BEL-P, BEL-A, and BM cell line datasets into the Reactome Pathway Knowledgebase. The top 20 pathways with false discovery rate of Q < 0.05 are shown.