Table 1.
Clinicopathologic characteristics of colorectal cancer patients by Fusobacterium nucleatum (Fn) abundance in iecal biospecimen.
| Characteristcs | Total |
Fn-Negative/Low1 |
Fn-High1 |
P-value2 | |||
|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | ||
| Total | 105 | 83 | 79.0 | 22 | 21.0 | ||
| ColoCare Study Site | 0.36 | ||||||
| University of Heidelberg, Germany | 75 | 71.4 | 61 | 73.5 | 14 | 63.6 | |
| Huntsman Cancer Institute, Utah | 30 | 28.6 | 22 | 26.5 | 8 | 36.4 | |
| Patient Sex | 0.56 | ||||||
| Female | 42 | 40.0 | 32 | 38.6 | 10 | 45.5 | |
| Male | 63 | 60.0 | 51 | 61.5 | 12 | 54.6 | |
| Age at Surgery | 0.24 | ||||||
| <65 years | 60 | 57.1 | 45 | 54.2 | 15 | 68.2 | |
| 65+ years | 45 | 42.9 | 38 | 45.8 | 7 | 31.8 | |
| Mean, years, (SD) | 63.5 | (11.7) | 63.8 | (11.7) | 62.5 | (11.5) | 0.64 |
| Body Mass Index 3 | 0.48 | ||||||
| Underweight/Normoweight (<25 kg/m2) | 32 | 32 | 23 | 29.1 | 9 | 42.9 | |
| Overweight (25–29.99 kg/m2) | 41 | 41 | 34 | 43.0 | 7 | 33.3 | |
| Obese (30+ kg/m2) | 27 | 27 | 22 | 27.9 | 5 | 23.8 | |
| Mean kg/m2, (SD) | 27.6 | (5.9) | 27.4 | (4.9) | 28.2 | (8.8) | 0.68 |
| Tumor Stage | 0.43 | ||||||
| Stage I | 35 | 33.3 | 29 | 34.9 | 6 | 27.3 | |
| Stage II | 32 | 30.5 | 27 | 32.5 | 5 | 22.7 | |
| Stage III | 33 | 31.4 | 24 | 28.9 | 9 | 40.9 | |
| Stage IV | 5 | 4.8 | 3 | 3.6 | 2 | 9.1 | |
| Tumor Grade 4 | 0.60 | ||||||
| Well Differentiated | 11 | 10.7 | 9 | 11.0 | 2 | 9.5 | |
| Moderately Differentiated | 75 | 72.8 | 61 | 74.4 | 14 | 66.7 | |
| Poorly Differentiated | 17 | 16.5 | 12 | 14.8 | 5 | 23.8 | |
| Tumor Site | 0.06 | ||||||
| Colon | 70 | 66.7 | 59 | 71.1 | 11 | 50.0 | |
| Right-sided Colon | 33 | 47.1 | 29 | 49.2 | 4 | 36.4 | 0.14 |
| Left-sided Colon | 37 | 52.9 | 30 | 50.8 | 7 | 63.6 | |
| Rectosigmoid Junction and Rectum | 35 | 33.3 | 24 | 28.9 | 11 | 50.0 | |
| H. pylori infection 5 | 0.86 | ||||||
| None | 65 | 92.9 | 54 | 93.1 | 11 | 91.7 | |
| Yes | 5 | 7.1 | 4 | 6.9 | 1 | 8.3 | |
| Microsatellite Status 6 | 0.42 | ||||||
| Microsatellite Stable (MSS) | 65 | 80.2 | 51 | 78.5 | 14 | 87.5 | |
| Microsatellite Instable (MSI) | 16 | 19.8 | 14 | 21.5 | 2 | 12.5 | |
| Alcohol Consumption 7 | 0.74 | ||||||
| None | 9 | 11.7 | 7 | 11.1 | 2 | 14.3 | |
| Yes | 68 | 88.3 | 56 | 88.9 | 12 | 85.7 | |
| Smoking History 8 | 0.11 | ||||||
| Never Smoker | 42 | 424 | 29 | 37.2 | 13 | 61.9 | |
| Current Smoker | 19 | 19.2 | 17 | 21.8 | 2 | 9.5 | |
| Former Smoker9 | 38 | 38.4 | 32 | 41.0 | 6 | 28.6 | |
| Family History of CRC 10 | 0.63 | ||||||
| None | 94 | 93.1 | 73 | 92.4 | 21 | 95.5 | |
| Yes | 7 | 6.9 | 6 | 7.6 | 1 | 4.5 | |
Among CRC patients with detectable Fn levels, individuals were median split by Fn relative abundance (n=22 low; n=22 high; HD: low<0.034; high>0.034; HCI: low<0.00067; high>0.00067).
P-values do not include unknown values.
Five patients had unknown information on body mass index.
Two patients had unknown information on tumor grade.
Thirty-five patients had unknown information on H. pylori infection status.
Twenty-four patients had unknown information on microsatellite instability.
Alcohol Consumption within last 2+ years; Twenty-eight patients had unknown information on Alcohol Consumption.
Six patients had missing information on smoking history.
Stopped smoking 2+ years ago.
Four patients had unknown information on family history of CRC.
Abbreviations: SD, standard deviation; Fn, Fusobacterium nucleatum; CRC, colorectal cancer.