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DDAH‐2 overexpression in ECs inhibits deleterious effect of UA on oxidative stress and proinflammatory response in aortas of apoe−/− mice. Levels of (A) MDA, (B) TNF-α, IL-1β, IL-6, MCP-1, and MIP-2. (C) Western blots of ICAM-1, VCAM-1, and α-tubulin in aortas. Data are expressed as means ± SEMs of 10 mice. *Statistically significant difference (P < 0.05) relative to oxonic acid-treated apoe−/− mice.
