Table 1.
Characteristics of 2253 SPRINT participants with CKD stratified by Frailty Index and Cognitive Status.
| Characteristics | Fit (FI < 0.10) (n=251) |
Less Fit (0.10 > FI ≤
0.21) (n=1196) |
Frail (FI > 0.21) (n=806) |
MoCA < 24 (n=1298) |
|---|---|---|---|---|
|
Mean ±
SD
|
||||
| Age, years | 73.8 (8.8) | 73.4 (8.6) | 72.7 (9.7) | 74.7 (8.8) |
| Male Sex | 163 (65) | 737 (62) | 449 (56) | 813 (63) |
| Black Race | 54 (22) | 263 (22) | 247 (31) | 396 (31) |
| Some College or Greater | 196 (78) | 896 (75) | 505 (63) | 505 (63) |
| Body mass index, kg/m2 | 27.6 (4.6) | 29.3 (5.5) | 30.5 (6.5) | 29.4 (5.8) |
| Current Smoking | 5 (5) | 82 (14) | 111 (21) | 113 (16) |
| Depression Score | 0.75 (1.5) | 1.9 (2.5) | 5.5 (5.1) | 3.0 (3.9) |
| eGFR, mL/min/1.73m2 | 49.5 (8.5) | 46.9 (9.9) | 43.4 (11.1) | 45.7 (10.5) |
| Urine ACR, mg/g | 64.4(200.3) | 64.3 (154.3) | 105.2 (294.0) | 84.6 (237.0) |
| Urine creatinine, mg/g | 124.6 (76.3) | 124.4 (72.8) | 123.9 (74.8) | 124.4 (70.9) |
| SBP, mmHg | 138.5 (14.0) | 139.1 (16.1) | 140.9 (17.2) | 140.2 (16.2) |
| DBP, mmHg | 74.2 (9.6) | 74.0 (11.9) | 75.1 (13.3) | 73.5 (12.3) |
| Treated by diuretic | 112 (45) | 644 (54) | 455 (56) | 694 (54) |
| Treated by ARB or ACEi | 153 (61) | 750 (63) | 501 (62) | 792 (61) |
| LDL Cholesterol | 106.3 (26.6) | 107.5 (33.4) | 103.5 (38.2) | 105.4 (33.9) |
| Biomarkers | Median (IQR) | |||
| IL-18, pg/mL | 27.6 (15.7, 48.1) | 30.1 (15.9, 55.6) | 33.3 (17.4, 60.2) | 31.0 (16.8, 56.8) |
| NGAL, ng/mL | 24.2 (13.6, 50.2) | 26.9 (14.6, 53.6) | 31.0 (16.2, 66.5) | 29.3 (15,7, 61.1) |
| YKL-40, pg/mL | 590.8 (248.4, 1235.6) | 528.5 (217.7, 1120.9) | 585.9 (214.6, 1476.8) | 568.6 (221.7, 1334.0) |
| KIM-1, pg/mL | 741.9 (294.3, 1279.9) | 850.3(384.9, 1574.8) | 918.6 (425.0, 1737.2) | 846.3 (416.5, 1586.3) |
| MCP-1, pg/mL | 153.7 (80.1, 287.3) | 179.0 (89.0, 318.9) | 188.5 (98.0, 346.5) | 183.9 (96.2, 326) |
| α1M, mg/g | 12.8 (6.6, 21.9) | 12.9 (7.2, 24.4) | 14.7 (7.9, 28.0) | 14.5 (7.6, 25.8) |
| β2M, ng/mL | 104.2(44.0, 327.3) | 96.0 (38.1, 293.2) | 109.1 (37.6, 382.0) | 114.2 (43.0, 342.0) |
| Umod, ng/mL | 6.9 (4.8, 9.9) | 7.0 (4.6, 10.4) | 5.9 (3.9, 9.5) | 6.6 (4.5, 9.9) |
| Urine Albumin, mg/L | 12.0 (6.0, 42.0) | 15.0 (7.0, 41.0) | 21.0 (8.0, 73.0) | 17.0 (8.0, 50.0) |
Note. Values for continuous variables are given as mean ± standard deviation; those for categorical variables, as count (percentage).
Abbreviations: eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; ARB, angiotensin II receptor blocker; ACEi, angiotensin-converting enzyme inhibitor; LDL, low-density lipoprotein; IL-18, interleukin-18; KIM-1, kidney injury molecule 1; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1, monocyte chemoattractant protein 1; β2M, β−2 microglobulin; α1M, α−1 microglobulin; Umod, uromodulin.