Table 2.
NAFLD-MESA Index and NAFLD-Clinical Index Predictors (Derivation Set, n = 4131)
| Predictor | NAFLD-MESA Index | NAFLD-Clinical Index | ||
|---|---|---|---|---|
| Coefficient (95% CI) | Points | Coefficient (95% CI) | Points | |
| BMI category (kg/m2)* | ||||
| Normal | 0 | 0 | 0 | 0 |
| Overweight | 0.9 (0.3, 1.5) | 3 | 1.3 (0.7, 1.9) | 6 |
| Obese, grade 1 | 1.6 (1.0, 2.1) | 5 | 2.1 (1.6, 2.7) | 9 |
| Obese, grade 2 | 2.1 (1.5, 2.7) | 6 | 2.7 (2.1, 3.3) | 11 |
| GGT quartile (U/L) | ||||
| First (< 5) | 0 | 0 | – | – |
| Second (5–7.9) | 0.6 (0, 1.1) | 2 | – | – |
| Third (8–13.9) | 1.3 (0.8, 1.9) | 4 | – | – |
| Fourth (≥ 14) | 1.8 (1.3, 2.4) | 5 | – | – |
| Triglycerides† (mg/dL) | ||||
| < 75 | 0 | 0 | – | – |
| 75–149 | 1.8 (1.0, 2.5) | 5 | – | – |
| ≥ 150 | 2.0 (1.2, 2.8) | 6 | – | – |
| Female sex | 0.6 (0.3, 0.9) | 2 | 0.3 (0.0, 0.5) | 1 |
| Cigarette smoking history | ||||
| Never | 0.8 (0.3, 1.3) | 2 | 0.5 (0.0, 1.0) | 2 |
| Former | 0.5 (0.0, 1.0) | 1 | 0.2 (− 0.3, 0.7) | 1 |
| Current | 0 | 0 | 0 | 0 |
| Age category (years) | ||||
| 44–64 | 1.6 (0.9, 2.4) | 5 | 1.8 (1.0, 2.5) | 8 |
| 65–74 | 1.3 (0.5, 2.1) | 4 | 1.3 (0.6, 2.1) | 6 |
| 75–84 | 0 | 0 | 1 | 0 |
| Type 2 diabetes‡ | 0.3 (0, 0.7) | 1 | 0.5 (0.2, 0.8) | 2 |
| Race/ethnicity§ | ||||
| White | 0.9 (0.5, 1.3) | 3 | 1.0 (0.6, 1.4) | 4 |
| African American | 0 | 0 | 0 | 0 |
| Hispanic | 1.0 (0.6, 1.4) | 3 | 1.3 (0.9, 1.6) | 5 |
| Chinese American | 1.0 (0.5, 1.6) | 3 | 1.3 (0.8, 1.8) | 6 |
*BMI cut-points are < 25 normal, 25–< 30 overweight, 30–< 35 obese grade 1 for whites, African Americans, and Hispanics, and ≥ 35 obese, grade 2 for whites, African Americans, and Hispanics. < 23 normal, 23–< 27.5 overweight, and ≥ 27.5 obese for Chinese Americans
†Fasting sample
‡Defined as having fasting blood glucose ≥ 126 mg/dL, or on anti-diabetic medications
§Self-reported