Figure 1.

Predicted plasma concentration–time profile in patients with varying kidney function and a loading dose of 0.33 g. Patients with varying renal function (creatinine clearance according to Cockcroft and Gault⁹ 0–160 mL/min, step-size: 10 mL/min, respective numbers in the plots indicate the individual creatinine clearance), albumin was fixed to 2.8 g/dL, body weight was fixed to 70 kg. Daily doses of 1.5 g were administered for patients with creatinine clearances of 0–30 mL/min, 3 g for creatinine clearances 40–80 mL/min and 6 g for patients with creatinine clearances 90–160 mL/min. Line: median concentration, Shaded area: 90% prediction interval, Horizontal dotted line: 4 × S/I breakpoint of Pseudomonas aeruginosa according to¹².