FIG. 5.

Diagram depicting components of the signaling pathway hypothesized to play a role in cellular stress-mediated induction of type B CA-VI. Cellular stress leads to the induction of the chop gene and accumulation of CHOP protein. The latter forms a dimer with a member of the C/EBP family, and this activates the type B CA-VI promoter. Intracellular accumulation of CA-VI is predicted to increase the proton concentration in the cell by promoting the hydration of CO₂ produced by the metabolic activity of the cell.