Table 1.

Changes in neutrophils after the first pegfilgrastim administration (n = 21)^a,b

	Day 0c,d	Day 14c,d	P value
WBC	5395 (2700–8500)	10,838 (5500–19,200)	< 0.001
Neutrophil rate	57.3% (41.8–67.1)	77.2% (59.2–84.2)	< 0.001
Absolute neutrophil count	3126 (1463–5542)	8492 (3300–15,110)	< 0.001
CRP	0.10 (0.03–0.63)	0.37 (0.02–1.45)	0.011

^aMean age was 49.8 (range 33–64). ^bAll patients were given dose-dense EC (E: epirubicin 90 mg/m², C: cyclophosphamide 600 mg/m²) and pegfilgrastim (3.6 mg) was administered 1–3 days later. ^cThe day of the first dose-dense EC administration was counted as Day 0. ^dMean (range)