Fig. 3. Effect of photodynamic therapy (PDT) on intratumoral retention of proteins.

Representative whole-body fluorescence images of a 4T1 tumor–bearing nude mice with an implanted IMOD (white arrow) that received PDT (red, −4 h) and Cy7–bovine serum albumin (BSA) via IMOD (0 h). b 4T1 tumor–bearing nude mice that received Cy7-BSA via IMOD (0 h). In both panels, the tumors are indicated with white dashed circles. c Time course of normalized intratumoral Cy7 intensity over 1 week (n = 4–6) for the mice shown in (a) and (b). Data are medians ± quartiles. Asterisks indicate P < 0.05, determined using Mann–Whitney U-tests.