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. 2021 Aug 26;12:5138. doi: 10.1038/s41467-021-25391-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The panels show data for E0771 tumors (n = 6–14) in C57BL/6 mice that were untreated or were treated with PDT (q3d × 2) via an implanted IMOD, or ICB antibodies (i.p. q3d × 3), or PDT (q3d × 2) and ICB antibodies (daily) via IMOD (referred to as IMOD/PDT × 2/ICB (daily)). Tumors were collected on day 9 or 10 after the start of treatment and were analyzed by flow cytometry (for mice receiving combination regimen, the collection of tumor started on day 8 while tumor sizes were ~100 mm³). a Frequencies of CD8⁺CD3⁺ effector T (T_eff) cells in TILs. b Frequencies of CD4⁺CD3⁺ T_eff cells in TILs. c Frequencies of CD25⁺Foxp3⁺ regulatory T (T_reg) cells in CD4⁺ TILs. d Frequencies of CD11b⁺Ly6G⁻Ly6C^hi myeloid-derived suppressor cells (MDSCs) in TILs. e Frequencies of CD44^hiCD62L^lo effector memory cells in CD8⁺ TILs. f Ratio of CD8⁺ T_eff cells to CD4⁺CD25⁺Foxp3⁺ T_reg cells. g Ratio of CD8⁺CD44⁺ T cells to CD4⁺CD25⁺Foxp3⁺ T_reg cells. h Ratio of CD8⁺ T_eff cells to MDSCs. i Frequencies of CTLA-4⁺PD-1⁺ cells in CD8⁺ TILs. Statistical significance is determined by Mann–Whitney U-tests. * P < 0.05, ** P < 0.01, *** P < 0.001. Source data and P values are provided in the Source data file.