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. 2021 Aug 26;12:5138. doi: 10.1038/s41467-021-25391-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The panels show data for E0771 tumors (n = 5–12) in C57BL/6 mice receiving different treatments. a Frequencies of proliferative cells (ki-67⁺) in isolated CD8⁺ TILs. b–g Frequencies of cytokine production in isolated CD8⁺ TILs after ex vivo stimulation. The graphs depict frequencies of proliferative (b) ki-67⁺IFN-γ⁺, (c) ki-67⁺TNF-α⁺, (d) ki-67⁺Gzmb⁺, (e) ki-67⁺IL-2⁺, and polyfunctional sets of (f) ki-67⁺TNF-α⁺IFN-γ⁺, and (g) ki-67⁺IFN-γ⁺IL-2⁺ cells in isolated CD8⁺ TILs. h, i Frequencies of progenitor (h) and terminally (i) exhausted CD8⁺ cells in isolated CD8⁺ TILs. j The ratio between terminally and progenitor exhausted CD8⁺ TILs. k Frequencies of PD-1⁺CD38⁺ cells in CD8⁺ TILs. l Frequencies of PD-1⁺LAG-3⁺ cells in CD8⁺ TILs. Statistical significance is determined by Mann–Whitney U-tests. *P < 0.05, **P < 0.01, ***P < 0.001. Source data and P values are provided in the Source data file.