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. 2021 Aug 26;41(8):BSR20210021. doi: 10.1042/BSR20210021

Figure 4. Construction of the lncRNA–miRNA–mRNA ceRNA regulatory network.

Figure 4

(A) The up-regulated lncRNA-down-regulated miRNA-up-regulated mRNA ceRNA regulatory network included 2 lncRNAs, 3 miRNAs and 97 mRNAs. (B) The down-regulated lncRNA-up-regulated miRNA-down-regulated mRNA ceRNA regulatory network included 5 lncRNAs, 13 miRNAs and 47 mRNAs. Red nodes indicate up-regulated RNAs, and green nodes indicate down-regulated RNAs. Triangles, ovals and rectangles indicate DE lncRNAs, DE miRNAs and DE mRNAs, respectively; ceRNA, competing endogenous RNA; DE, differentially expressed; lncRNAs, long noncoding RNAs; miRNAs, microRNAs.