Figure 8.

Schematic of myofiber stretch inducing MuSC deformation, and effect of fluid shear stress on myoblast mRNA expression. (A) MuSC in its niche on the host myofiber, embedded between the sarcolemma (yellow) and basal lamina (gray) and connected via transmembrane complexes, undergoing tensile strain and shear stress deformations upon myofiber stretch. (B) Myoblasts subjected to mechanical load by PFSS in vitro induce upregulation of NO and expression of factors known to promote proliferation. To see this figure in color, go online.