Table 2.

Univariate and multivariate Cox regression analyses for predictors of disease-free survival (DFS) in T4 colon cancer

Variable	DFS
	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Male sex	1.459	0.618–3.444	0.389
Age	0.995	0.966–1.025	0.737
Body mass index	1.012	0.890–1.150	0.861
CCI, < 4	0.642	0.278–1.482	0.299
Tumor location			0.897
Right	1.000
Left	1.057	0.460–2.429
Differentiation			0.006			0.005
WD, MD	1.000			1.000
PD, othersa	4.730	1.555–14.386		4.994	1.610–15.489
Size	0.929	0.747–1.156	0.510
T stage			0.058
pT4a	1.000
pT4b	0.383	0.142–1.034
Positive node	0.860	0.006–0.006	0.808
Invasion
Lymphatic	1.793	0.703–4.577	0.222
Vascular	3.752	0.503–27.969	0.197
Perineural	1.578	0.686–3.630	0.283
CEA	0.992	0.971–1.014	0.491
Laparoscopic	0.332	0.144–0.762	0.009	0.323	0.140–0.747	0.008
Adjuvant chemotherapy	1.425	0.329–6.169	0.635

HR, hazard ratio; CI, confidence interval; CCI, Charlson comorbidity index; WD, well differentiated; MD, moderate differentiated; PD, poorly differentiated; p, pathologic; CEA, carcinoembryonic antigen.

^aMucinous carcinoma and signet ring cell.