Table 3.

Univariate and multivariate Cox regression analyses for predictors of overall survival (OS) in T4 colon cancer

Variable	OS
	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Male sex	1.175	0.544–2.538	0.682
Age	1.004	0.974–1.036	0.778
Body mass index	1.106	0.977–1.251	0.112
CCI, < 4	1.109	0.514–2.393	0.792
Tumor location			0.024			0.289
Right	1.000			1.000
Left	0.346	0.138–0.869		0.583	0.215–1.582
Differentiation			< 0.001			< 0.001
WD, MD	1.000			1.000
PD, othersa	6.924	2.704–17.726		7.904	2.827–22.101
Size	0.859	0.703–1.048	0.134
T stage			0.883
pT4a	1.000
pT4b	0.923	0.319–2.675
Positive nodes	1.203	0.550–2.632	0.643
Invasion
Lymphatic	1.248	0.374–4.156	0.719
Vascular	0.787	0.367–1.688	0.539
Perineural	1.566	0.714–3.436	0.263
CEA	0.999	0.984–1.013	0.841
Laparoscopic	0.421	0.197–0.900	0.026	0.550	0.253–1.196	0.132
Adjuvant chemotherapy	0.354	0.146–0.857	0.021	0.344	0.125–0.944	0.038

HR, hazard ratio; CI, confidence interval; CCI, Charlson comorbidity index; WD, well differentiated; MD, moderate differentiated; PD, poorly differentiated; p, pathologic; CEA, carcinoembryonic antigen.

^aMucinous carcinoma and signet ring cell.