Table 3.

Definitive β-Lactam Therapy Management

Variable	Total	Obese	Nonobese	P Value
	(N = 589)	(n = 257)	(n = 332)
Definitive antibiotic selection
β-lactam/β-lactamase inhibitors	1 (0.2)	1 (0.4)	0 (0)	.436
First-generation cephalosporins	47 (8)	14 (5.4)	33 (9.9)	.046
Third-generation cephalosporins	276 (46.9)	128 (49.8)	148 (44.6)	.207
Cefepime	263 (44.7)	113 (44)	150 (45.2)	.769
Anti-pseudomonal carbapenems	2 (0.3)	2 (0.8)	0 (0)	.190
Definitive drug regimens
Piperacillin-tazobactam 3.375 g q6h	1 (100)	1 (100)	0 (0)
First-generation cephalosporins
500 mg q8h	1 (2.1)	0 (0)	1 (3)	1.000
1 g q8h	27 (57.4)	9 (64.3)	18 (54.5)	.537
1 g q12h	3 (6.4)	0 (0)	3 (9.1)	.544
1 g q24h	1 (2.1)	1 (7.1)	0 (0)	.298
2 g q8h	14 (29.8)	4 (28.6)	10 (30.3)	1.000
2 g q12h	1 (2.1)	0 (0)	1 (3)	1.000
Third-generation cephalosporins
0.5 g q24h	1 (0.4)	1 (0.8)	0 (0)	.464
1 g q8h	1 (0.4)	1 (0.8)	0 (0)	.464
1 g q12h	3 (1.1)	2 (1.6)	1 (0.7)	.598
1 g q24h	215 (77.9)	94 (73.4)	121 (81.8)	.097
2 g q12h	2 (0.7)	0 (0)	2 (1.4)	.501
2 g q24h	54 (19.6)	30 (23.4)	24 (16.2)	.132
Cefepime
0.5 g q24h	2 (0.8)	0 (0)	2 (1.3)	.508
1 g q6h	72 (27.4)	27 (23.9)	45 (30)	.272
1 g q8h	85 (32.3)	37 (32.7)	48 (32)	.898
1 g q12h	37 (14.1)	14 (12.4)	23 (15.3)	.497
1 g q24h	25 (9.5)	14 (12.5)	11 (7.3)	.166
2 g q8h	22 (8.4)	14 (12.4)	8 (5.3)	.041
2 g q12h	12 (4.6)	2 (1.8)	10 (6.7)	.060
2 g q24h	8 (3)	5 (4.4)	3 (2)	.295
Anti-pseudomonal carbapenems 1 g q6h	2 (100)	2 (100)	0 (0)
Duration of definitive therapy, days
β-lactam/β-lactamase inhibitors	2 days	2 days	…
First-generation cephalosporins, median (IQR)	5 (4–7)	5 (4–6)	6 (4–7.5)	.364
Third-generation cephalosporins, median (IQR)	4 (3–6)	4 (3–6)	4 (3–6)	.169
Cefepime, median (IQR)	5 (4–7)	5 (4–7)	5 (4–7)	.216
Anti-pseudomonal carbapenems	4 days, 8 days	4 days, 8 days	…

Data are presented as No. (%) unless otherwise indicated.

Abbreviations: IQR, interquartile range; q6h, every 6 hours; q8h, every 8 hours; q12h, every 12 hours; q24h, every 24 hours.