Table 2. Risk of Primary Ovarian Insufficiency by Vaccination Status.
| Characteristic | Diagnoses, No. | Person-years | HR (95% CI) | |
|---|---|---|---|---|
| Crudea | Adjustedb | |||
| Vaccination status | ||||
| Unvaccinated | 90 | 4 021 340 | 1 [Reference] | 1 [Reference] |
| Vaccinatedc | 54 | 2 759 826 | 1.16 (0.78-1.73) | 0.96 (0.55-1.68) |
| Time since last vaccination, d | ||||
| 0-90 | 6 | 304 262 | 1.64 (0.69-3.92) | 1.01 (0.37-2.70) |
| 91-365 | 11 | 449 138 | 1.76 (0.89-3.50) | 0.99 (0.44-2.22) |
| ≥366 | 37 | 2 006 425 | 1.01 (0.65-1.57) | 0.94 (0.49-1.80) |
| Age at first vaccination, y | ||||
| 11-19 | 32 | 2 024 850 | 0.98 (0.56-1.72) | 0.77 (0.37-1.62) |
| 20-4 | 22 | 734 976 | 1.34 (0.80-2.22) | 1.15 (0.58-2.28) |
| Calendar period at first vaccination | ||||
| 2007-2011 | 32 | 1 847 162 | 1.01 (0.61-1.66) | 0.75 (0.39-1.45) |
| 2012-2016 | 22 | 912 663 | 1.36 (0.82-2.24) | 1.42 (0.67-2.99) |
Abbreviation: HR, hazard ratio.
a
The underlying time scale is age.
b
The baseline hazard is stratified by calendar period in 1-year categories and propensity score in 10 categories by deciles.
c
Unaccinated individuals serve as reference group for all HRs.