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. 2021 Aug 16;13(16):4118. doi: 10.3390/cancers13164118

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Prognosis value for splicing-related genes with CNAs. Splicing-related genes (only showed those genes with high amplification in >5% of patients) with higher prognostic value based on hazard ratio and p values (A). List of genes showing significant association between expression levels and detrimental prognosis in RFS (KM Plotter software was used) (B). Prognostic value (OS) of selected genes (based on: p < 0.002, HR > 1.5; FDR < 5 from KM Plotter) was confirmed using genotype-2-outcome web-server (C). Summary of outcome results obtained to LSM1, CLNS1A, and ILF2 in the Luminal A subtype (D). Kaplan-Meier plots (OS and RFS) for the combination of these three genes using KM Plotter software (E) and their validation in another Luminal A cohort (TCGA project) (F).