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. 2021 Aug 10;10(8):2049. doi: 10.3390/cells10082049

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Methylation dynamics during mouse embryonic preimplantation development. After fertilization, the male genome (blue) undergoes fast demethylation, whereas the female genome (pink) undergoes a slow passive DNA demethylation. De novo methylation occurs at the blastocyst stage, with a differential methylation pattern between the ICM and the TE. Specific histone marks are present in the male and female genomes and in the embryo at different pre-implantation stages. Zy, zygote. C, cell. M, morula. B, blastocyst. ICM, inner cell mass. TE, trophectoderm.