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EC50 values and selected drug combinations for functional studies in prostate cell lines.
| Prostate Cell Lines | Hydralazine (uM) |
Enzalutamide (uM) |
Bicalutamide (uM) |
H+E (uM) |
|---|---|---|---|---|
| DU-145 | 34.1 | 14.6 | 59.0 | NS |
| LNCaP | 105.7 | 39.9 | 54.8 | 40 + 20 |
| PC-3 | 166.9 | 56.1 | 47.6 | 50 + 30 |
| C4-2 | 113.7 | 50.8 | 54.8 | 40 + 15 |
| PNT1a | 88.6 | 45.5 | 70.3 | NT |
| RWPE-1 | 115.0 | 74.9 | 49.4 | NT |
H+E—combination of hydralazine and enzalutamide, NS—no synergistic effect; NT—not tested.
