Table 1.

Major NRTKs and their targets in the Pyk2-Src-Arg-cortactin invadopodial pathway.

NRTK	Target	Role in Invadopodia	Reference
Pyk2	Src	Pyk2 recruits and activates Src in invadopodia.	[40]
	Cortactin	Pyk2 tyrosine phosphorylates cortactin both directly and indirectly by recruiting and activating Src, which activates Arg to phosphorylate cortactin.	[40]
FAK	Src	FAK indirectly regulates invadopodium precursor formation and activation by sequestering Src to focal adhesions and away from invadopodia.	[26]
Src	Tks5	Src tyrosine phosphorylates Tks5 to regulate invadopodium precursor formation and stabilization.	[30,48,49]
	Arg	Src phosphorylates and activates Arg, which phosphorylates cortactin during invadopodium maturation and activation	[28]
Arg	Cortactin	Arg tyrosine phosphorylates cortactin in invadopodia, leading to invadopodium maturation and ECM degradation.	[28]
	Ras	Arg inhibits the Ras-MAPK pathway to block tumor cell proliferation.	[7]