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Tumor growth after 21 days in nude mice implanted with MDA-MB-231-Luc cell lines treated with costunolide (COS), doxorubicin (DOX), costunolide + doxorubicin (COS + DOX), costunolide-nanoparticles (COS-NPs), and costunolide-nanoparticles + doxorubicin (COS-NPs + DOX). (A) Tumor volumes (B) Tumor weight. (C,D) Bioluminescence signals. Values are presented as mean ± SD. * p < 0.05, ** p < 0.01, and *** p < 0.001.
