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. 2021 Aug 10;9(8):990. doi: 10.3390/biomedicines9080990

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histopathological assessment of heart sections in (A) HCT116 colon cancer cells implant and (B) MDA-MB-231-Luc breast cancer cells implant treated with costunolide (COS), doxorubicin (DOX), costunolide + doxorubicin (COS + DOX), costunolide-nanoparticles (COS-NPs), and costunolide-nanoparticles + doxorubicin (COS-NPs + DOX). Black arrows refer to cellular damages of doxorubicin (DOX). Scale bar shows magnification 40×.