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. 2021 Jul 28;9(8):949. doi: 10.3390/healthcare9080949

Table 3.

Ongoing studies on the use of repetitive transcranial magnetic stimulation in dementia.

NCT Number Dementia Type Details
NCT02621424 MCI */AD **

  • Last update: May 2021, active—not recruiting

  • Randomized, crossover, sham-controlled

  • Target: DLPFC *5

  • Outcome: Cognitive score improvement and CSF *6 BDNF *7 levels
NCT01894620 AD

  • Last update: February 2021, completed, preliminary results listed

  • Randomized, crossover, sham-controlled

  • Outcome: Cognitive score and sleep improvement
NCT02537496 AD

  • Last update: February 2019, completed, no results listed

  • Randomized, sham-controlled

  • Target: Left DLPFC

  • Outcome: Executive function/working memory improvement
NCT04562506 AD

  • Last update: September 2020, completed

  • Randomized, sham-controlled, double-blinded

  • Target: Bilateral DLPFC

  • Outcome:Cognitivefunctions
NCT03665831 MCT/AD with comorbid MDD *3

  • Last update: October 2019, recruiting

  • Open-label trial

  • Target: Left DLPFC

  • Outcome: Emotional/cognitive symptoms
NCT02908815 AD

  • Last update: February 2021, recruiting

  • Randomized, sham-controlled

  • Target: DLPFC

  • Outcome: Cognitive functions
NCT01885806 AD-related apathy

  • Last update: June 2013, unknown

  • Randomized, sham-controlled

  • Target: Left DLPFC

  • Outcome: Apathy symptoms
NCT04754152 MCI/AD

  • Last update: May 2021, recruiting

  • Randomized, sham-controlled

  • Outcome: Cognitive functions
NCT04012346 MCI/AD

  • Last update: July 2019, unknown

  • Randomized, double-blinded, sham-controlled

  • Outcome: Cognitive functions
NCT04042532 Early onset AD

  • Last update: April 2021, enrolling by invitation

  • Randomized, double-blinded, sham-controlled

  • Target: Left DLPFC

  • Outcome: Cognitive functions
NCT04555941 MCI/AD

  • Last update: October 2020, recruiting

  • Randomized, triple-blinded, sham-controlled

  • Outcome: Cognitive functions
NCT01481961 Early AD

  • Last update: March 2015, completed

  • Open-label trial

  • Target: Left DLPFC

  • Outcome: Cognitive functions
NCT03612622 MCI/Early AD

  • Last update: February 2021, completed

  • Randomized, triple-blinded, sham-controlled

  • Outcome: Associative memory/cognitive and psychological symptoms
NCT04440891 AD

  • Last update: April 2021, recruiting

  • Randomized, double-blinded, sham-controlled

  • Outcome: Cognitive functions
NCT03270137 AD

  • Last update: September2017, unknown

  • Randomized, single-blinded

  • Target: Left DLPFC/six region protocol

  • Outcome: Cognitive functions
NCT04263194 Mild AD

  • Last update: August 2020, recruiting

  • Randomized, triple-blinded, sham-controlled

  • Target: DMN *8

  • Outcome: Cognitive symptoms
NCT03778151 Mild AD

  • Last update: February 2021, completed

  • Randomized, double-blinded, sham-controlled

  • Target: DMN

  • Outcome: Cognitive symptoms
NCT04294888 Prodromal and Preclinical AD

  • Last update: March 2020, recruiting

  • Randomized, cross-over, single-blinded, sham-controlled

  • Target: DMN

  • Outcome: Associative memory/functional connectivity
NCT04045990 Amnestic MCI/Logopenic PPA *4

  • Last update: November 2020, recruiting

  • Cross-over, single-blinded, sham-controlled

  • Target: DMN

  • Outcome: Language/memory
NCT03406429 Agrammatic Non-Fluent PPA/Logopenic PPA

  • Last update: March 2021, recruiting

  • Open-label, cross-over, sham-controlled

  • Target: Left DLPFC

  • Outcome: Language/functional connectivity and cortical thickness
NCT04188067 PPA

  • Last update: February 2021, recruiting

  • Open-label, cross-over, sham-controlled

  • Target: Left DLPFC

  • Outcome: Language/functional connectivity
NCT04193267 Logopenic PPA

  • Last update: March 2021, recruiting

  • Open-label trial

  • Target: Left superior temporal gyrus

  • Outcome: Language
NCT04431401 PPA

  • Last update: June 2020, not yet recruiting

  • Randomized, triple-blinded, sham-controlled

  • Outcome: Language/functional connectivity
NCT03153540 Agrammatic Non-Fluent PPA

  • Last update: January 2021, recruiting

  • Randomized, cross-over, quadruple-blinded, sham-controlled

  • Target: Dominant inferior frontal gyrus

  • Outcome: Safety, tolerability/language/brain function
NCT03448133 PPA

  • Last update: June 2020, withdrawn

* Mild Cognitive Impairment. ** Alzheimer’s Disease. *3 Major Depressive Disorder *4 Primary Progressive Aphasia. *5 Dorsolateral Prefrontal Cortex. *6 Cerebrospinal Fluid. *7 Brain-Derived Neurotrophic Factor. *8 Default Mode Network.