Figure 3.

Functional association between USP19 and DNA double-strand (DSB) repair genes such as BRCA1/2. (A,B) Co-expression pattern among USP19, 18 DSB repair genes, and two candidate genes in our patients with HGSC and TCGA datasets, respectively. (C) Violin plot depicting USP19 expression according to the BRCA1/2 mutation in our patients. (D) Sub-network of functional associations among USP19 and hereditary pathogenic genes responsible for causing breast and ovarian cancer syndrome. Node color represents the characteristics of genes; red: USP19, green: DSB repair genes, blue: gene connecting USP19 to DSB repair genes.