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. 2021 Aug 22;9(8):1065. doi: 10.3390/biomedicines9081065

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Verification of the butyric acid and EPA-related metabolites inducing efficacy by CBM 588 based on targeted long-chain fatty acid metabolites profiles. Metabolic pathway for PUFAs and SCFAs in mouse colon contents. The signal intensities of metabolites were compared using the average values of each group. The vertical axis indicates the signal intensity. The vertical axis of the SCFAs is the concentration (µg/g). (A) Conjugated linoleic acid (B) Anti-inflammatory lipid mediators. (C) Arachidonic acid metabolites. (D) Saturated fatty acids. (E) Organic acids. Values represent mean ± SD (n = 5). Statistical significance was set at p < 0.05. * p < 0.05, compared with control. HEPE: hydroxyeicosapentaenoic acid, HETrE: hydroxyeicosatrienoic acids, HETE: hydroxyeicosatrienoic acid, LXB₄: lipoxin B₄.