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. 2021 Aug 22;9(8):1065. doi: 10.3390/biomedicines9081065

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The gut microbe altered by CBM 588 and/or protectin D1 upregulates host fatty acid receptors, lipid elongation enzymes, and immune cell signaling factors. (A) Relative RNA levels of genes-encoding enzymes related to fatty acid metabolism and signal factors of immune cells in colon tissue of mice. (B) Concentrations of GPR41, GPR109a, GPR120, FADS1, ELOVL5, and GATA-3 in colon tissues of mice. Relative RNA levels of each target gene were normalized to those in the control group (represented as RQ on the vertical axis). Values represent mean ± SD (n = 5). Statistical significance was set at p < 0.05. * p < 0.05, compared with control.