Table 5.
Univariate and multivariable Cox regression analysis for progression-free and overall survival.
| Parameters | Progression-Free Survival (PFS) | Overall Survival (OS) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariable | Univariate | Multivariable | ||||||
| Cutoff | Hazard Ratio | p Value | Hazard Ratio | p Value | Hazard Ratio | p Value | Hazard Ratio | p Value | |
| Age (y) | 60 | 1.0 (0.5–1.8) | >0.99 | 1.0 (0.6–1.9) | 0.89 | ||||
| sex | M vs. F | 0.5 (0.2–1.3) | 0.18 | 1.0 (0.4–2.4) | 0.98 | ||||
| Size (cm2) | 17.5 | 0.9 (0.5–1.7) | 0.82 | 0.4 (0.2–0.8) | 0.006 * | ||||
| ECOG | 0 vs. 1 | 0.9 (0.4–2.1) | 0.89 | 1.0 (0.4–2.1) | 0.93 | ||||
| Child | 5 vs. 6 | 1.1 (0.6–2.0) | 0.74 | 1.2 (0.7–2.3) | 0.48 | ||||
| AFP (ng/mL) | 400 | 0.9 (0.5–1.7) | 0.78 | 0.8 (0.4–1.5) | 0.49 | ||||
| Cirrhosis | No vs. yes | 0.7 (0.4–1.5) | 0.39 | 0.9 (0.4–1.8) | 0.71 | ||||
| Macroscopic vascular invasion | No vs. yes | 0.99 (0.5–1.8) | 0.98 | 1.8 (1.0–3.4) | 0.06 | ||||
| Extrahepatic spread | No vs. yes | 1.1 (0.4–2.8) | 0.89 | 1.0 (0.4–2.7) | 0.97 | ||||
| PFS/OS | |||||||||
| Peak (%) | 32.5/16.8 | 0.7 (0.4–1.4) | 0.35 | 0.6 (0.3–1.4) | 0.23 | ||||
| Slope (1/s) | 21.4/22.4 | 0.5 (0.3–0.9) | 0.024 * | 0.6 (0.3–1.1) | 0.11 | 0.4 (0.2–0.8) | 0.01 * | 0.3 (0.2–0.7) | 0.003 * |
| AUC (/10 s) | 1115/3689 | 0.5 (0.2–1.3) | 0.15 | 1.7 (0.8–3.7) | 0.19 | ||||
| Ktrans (min−1/1000) | 51/21 | 0.8 (0.4–1.5) | 0.47 | 1.7 (0.5–5.5) | 0.42 | ||||
| Kep (min−1/1000) | 370/1730 | 0.2 (0.1–0.5) | <0.001 * | 0.2 (0.1–0.5) | <0.001 * | 0.7 (0.3–1.5) | 0.3 | ||
| Ve (%) | 6.5/11.1 | 0.7 (0.4–1.4) | 0.34 | 1.6 (0.9–3.0) | 0.11 | ||||
| ADC (10−3 mm2/s) | 0.943/1.138 | 0.3 (0.1–0.7) | 0.018 * | 0.3 (0.1–0.7) | 0.009 * | 0.5 (0.2–0.9) | 0.015 * | 0.3 (0.1–0.8) | 0.009 * |
| D (10−3 mm2/s) | 1.183/1.173 | 0.6 (0.2–1.3) | 0.2 | 0.6 (0.3–1.3) | 0.18 | ||||
| D* (10−3 mm2/s) | 10.9/10.9 | 2.5 (0.8–8.4) | 0.1 | 3.1 (0.9–10.3) | 0.051 | ||||
| f (%) | 28/23.4 | 0.6 (0.2–1.4) | 0.17 | 0.4 (0.2–0.8) | 0.012 * | 0.6 (0.3–1.1) | 0.1 | ||
Note—Data in parentheses are 95% confidence intervals. AUC = area under the curve; Ktrans = forward volume transfer constant; Kep = reverse rate transfer constant; Ve = extravascular extracellular space volume per unit volume of tissue; ADC = apparent diffusion coefficient; D = pure diffusion coefficient; D* = pseudodiffusion coefficient; f = perfusion fraction. * p value indicates significant difference as determined by Cox regression analysis.