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. 2021 Aug 12;11(8):1201. doi: 10.3390/biom11081201

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Schematic representation of PrP^C from mouse, turtle, and frog. PB: polybasic motif; β: cleavage site that generates N2; α: cleavage site that generates N1; HD: hydrophobic domain; arrows: β-strand; coils: α-helices; S-S: disulfide bridge; filled circles: N-linked glycans; GPI: glycosylphosphatidylinositol anchor. (B) Sequence alignments of PB1, PB2, and the HD. Identical residues are marked in black, similar residues in gray (GenBank accession numbers: M18070.1, XP_034617687.1, AAH94089.1). The numbering of the residues refers to mouse PrP^C.