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. 2021 Jul 27;12(8):1135. doi: 10.3390/genes12081135

Table 1.

Selection of genes associated with IOP and suggested molecular mechanisms.

Gene GWAS Identified Suggested Mechanism Reference
LMX1B Gao et al., 2018 [16] Altered Anterior Segment Development; Altered Aqueous Humor Dynamics Pressman et al., 2000 [17]
MADD Gao et al., 2018 [16] TNF-a-Mediated Microglial Activation Tezel et al., 2000 [18]
NR1H3 Gao et al., 2018 [16] Alteration of IOP via-ABCA1-Regulated Aqueous Humor Dynamic Alterations Hu et al., 2020 [19]
SEPT9 Gao et al., 2018 [16] Cytoskeletal Alterations Ou et al., 1998 [20]