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Schematic model showing the main role of HSPs in renal and cardiovascular diseases. HSP90, HSP70, HSP60 and HSP27 participate in pathophysiological mechanisms of renal and cardiovascular disorders, including the relationship between them in cardiorenal syndrome. HSP: heat shock proteins; CKD: chronic kidney disease; IRI: ischemia and reperfusion injury; eNOS: endothelial nitric oxide synthase.
