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. 2021 Aug 1;9(8):936. doi: 10.3390/biomedicines9080936

Figure 1.

Figure 1

Impact of s-cal14.2b on NIT-1 and primary hepatic and pancreatic cell viability in vitro. The CellTiter 96® Aqueous Cell Proliferation Assay was used to measure any changes to cell viability following treatment with 0.1, 1, and 5 µg/mL s-cal14.2b. (A) Cell viability of NIT-1 cells significantly decreased by 18% in response to 5 µg/mL s-cal14.2b (when compared to the negative control). (B) Cell viability of primary hepatocytes decreased by 15% and 14% following treatment with 1 and 5 µg/mL s-cal14.2b. (C) Cell viability of primary pancreatic significantly decreased by 20%, 24%, and 22% in response to 0.1, 1, and 5 µg/mL s-cal14.2b, C+ (s-cal14.1a) related peptide with cytotoxic activity, C- PBS 1x (s-cal14.2b solvent). Results are expressed mean ± SEM cell viability assays conducted in triplicate (n = 3). Statistical significance denoted by **** p < 0.0001 between control positive and s-cal14.2b concentrations.